How Does CBD Influence Your Body?

Mayo Clinic Minute: Is CBD safe to use?
Mayo Clinic Minute: Is CBD safe to use?

CBD is being touted to help treat nausea, anxiety, cancer, arthritis and even Alzheimer’s. Does it work? Patients, such as those being treated with cancer, s...


The global market for CBD is rapidly rising, and this compound has managed to fascinate people all around the world. CBD or cannabidiol is a non-psychoactive cannabinoid that constitutes the cannabis plant. The recent research about the plant in the field of medicine helped understand the value of this cannabinoids and how it can influence the health and wellness of its users.

The endocannabinoids system and CBD interaction

CBD`s interaction with the endocannabinoid system is the primary reason behind its impact on the body. The endocannabinoid system is the center for chemicals and neurotransmitters that control the functioning of various organs in the body. The perfect balance of chemicals always ensures that your body functions perfectly. When we consume cannabis, cannabinoids such as CBD and THC interact with our body’s CB receptors. They bind at these sites and trigger the release of certain chemicals that enables them to bring balance to the body.

There are two types of CB receptors, CB1 and CB2. The interaction of CBD with CB1 receptors is quite different from any other compound. It is, in fact, a strong allosteric modulator of CB1 receptor sites. It is among the crucial reason why, in the presence of THC, CBD helps reduce the psychoactive effects of the compound. The second type of receptors is CB2. These receptors are responsible for inflammation control in the body. CBD is an inverse agonist of these receptors as it helps maintain the functioning of the sites efficiently to reduce inflammation in the body.

Apart from this direct receptor site interaction, there are other ways in which CBD influences the endocannabinoid system. FAAH or Fatty acid amide hydrolase is an essential enzyme that controls the functioning of the endocannabinoid system. It performs the function of breaking down anandamide. CBD reduces the efficiency of the enzyme in breaking down the compound to increase the deposit of anandamide. It performs a similar function in the case of Fatty acid-binding protein and ensures that the anandamide does not get metabolized. This way, the concentration of it increases in the body, and one can receive the positive effects of the same.

CBD and Serotonin receptors

Among the various health benefits of CBD use, one of the areas where CBD has been found very effective is in the treatment of mental ailments such as anxiety. Research conducted at the University of San Paulo in Brazil and King’s College in London aims to correlate the neural effects of CBD on anxiety. The study indicates that at high concentrations, CBD is effective in activating the 5-HT1A or hydroxy tryptamine serotonin receptors that cause an anti-anxiety effect. The regulation of this protein receptor helps derive various benefits such as enhanced appetite, improve sleep patterns, counter for side effects of chemotherapy such as nausea and vomiting, anti-anxiety effects.

CBD and Vanilloid receptors

The therapeutic benefits of CBD are due to its interaction with ion channels. It binds switch the TRPV1 receptors that mediate perception of pain, body temperature, and control inflammation.

CBD with GPR-55 Receptors and PPARS receptors

GPR-55 is a receptor present majorly in the cerebellum that controls functions such as modulating blood pressure, bone density, and other physiological processes. This receptor is expressed in various cancer cells indicating that it can promote cancer cell proliferation. A study by the Chinese Academy of Sciences in Shanghai in 2010 proves this theory. CBD blocks the signaling of this receptor, thereby reducing cancer cell proliferation as well as bone reabsorption. This type of effect can be particularly beneficial to reduce and control the risk of various types of cancer.

Another way in which CBD helps reduce the risk of cancer is by activating the receptors known as PPAR- gamma. These receptors are present in the cell`s nucleus and help reduce tumor formation in the human lungs. Also, activating the receptors degrades amyloid-beta plaque, which is responsible for Alzheimer’s disease. The presence of CBD to activate PPARs can help decrease the risk of Alzheimer’s disease.

CBD and The Brain

Apart from the endocannabinoid system, the interaction of CBD with the human brain positively impacts the flow of chemicals here. It stimulates the serotonin pathway in the brain and relieves the users of stress, depression, anxiety, and migraine symptoms in the long run. CBD impacts the glial cells in the brain. It modulates the functioning of these cells that ensures that there is normal sensitivity to stimuli, thus reducing the perception of pain.

How does this interaction influence the body?

As we go through the various sites of interaction of CBD with our body, it is important to understand that each of these influences our health in many ways. The various health benefits possible from the compound happen as a result of these interactions. Some of the benefits of CBD on our body are

  1. Anti-inflammatory properties: CBD has powerful anti-inflammatory properties that come handy in the case of users suffering from chronic problems such as arthritis and multiple sclerosis. While CBD cannot take away the inflammation and pain completely, it reduces the perception of the same, making the condition more tolerable. A massage using CBD oil can help you achieve the best anti-inflammatory benefits from this incredible compound. Nowadays, so many people trust Getkush because it provides them with the best quality CBD oil at low prices.

  2. Anti-anxiety properties: CBD is a non-psychoactive component that helps relax the body by triggering the secretion of serotonin. It helps counter anxiety, depression, and various other mental health disorders and ensures emotional well-being. A study from the University of Montana indicates the same effect. CBD oil used through vaping, massages, tinctures, or any other method can be beneficial for the user.

  3. Treat insomnia: CBD, directly and indirectly, influences your sleep cycle. By countering the physical and mental problems such as anxiety, depression, and pain, CBD helps the users get a good night's sleep. It relaxes the body and mind and creates and enables people to sleep well during the night. It can also help eliminate daytime sleepiness and offer energy to carry with the activities of the day. Considering this property, manufacturers formulate CBD oil to treat insomnia among patients.

Compared to THC, CBD has a light binding effect with the CB receptors in the body. But CBD also binds with other receptors and ion channels that enable it to create the various effects on users. CBD is the ideal compound for all age groups to try and derive the most benefits out of the cannabis plant. It does not make you high, instead, it brings ample health benefits for both physical and mental wellness. The power of CBD and its interaction with the body is an incredibly fascinating subject to explore.

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